The crash along U.S. Highway 98 in the Silver Flag area of Tyndall Air Force closed the road, which was expected to remain closed for 24 hours, WJHG-TV, Panama City Beach, reported Wednesday.
Base and local police and safety officials said the highway was closed as a precaution after small fires broke out at the crash site.
Officials said they also had not determined if a self-destruct device on the drone had detonated. It is powered by a battery that is depleted after 24 hours.
It was the second such incident in the last two weeks. A drone was intentionally destroyed over the Gulf of Mexico on July 10 after base officials said they had been unable to land the aircraft.