Many drivers stopped their vehicles or pulled over to park when they saw the young girl in road, the South Florida Sun Sentinel said.
More than 38,000 vehicles pass through the intersection daily.
"It's one of those things you see it, you don't quite believe it," Robert Wisniewski, who saw the girl when he was driving, told the Sentinel. "Then it clicked in my head: 'Damn, that's a little girl in the road.'"
Once the toddler made it safely to the other side, a passerby told her to stay put and she listened.
Police found the girl's mother, Kayla Tamika Campbell, 26. She was arriving at a residence on a nearby street when police knocked on the door.
She said she had been gone for about 30 minutes and that her roommate was watching the girl, but the roommate told authorities she didn't know Campbell had left, and that she does not watch the child.
Campbell was arrested, charged with felony child neglect without bodily harm and is being held in lieu of $10,000 bail.
Police said the Florida Department of Children and Families will conduct an investigation.
The girl was placed in custody of her father.