Homeowner Jimmy Moore, 64, died, as did David Kuhns, his wife Crystal Kuhns and their children -- Skylar, 8, Shawn, 6, and Mickey, 4. Kordell Kuhns, 2, was in critical condition at Crozer Chester Medical Center, near Philadelphia, WGAL-TV, Lancaster, Pa., reported.
The four-alarm fire began around 3 a.m. Thursday, WHTM-TV, Harrisburg, Pa., reported.
Officials said 14 people, nine adults and five children, were in the home at the time of the fire.
The home was not equipped with smoke detectors.
Nine people were hospitalized, one of whom, Martha Jones, was pregnant and underwent an emergency C-section at the hospital, WGAL-TV said.