John Littig, 48, and his common-law wife, Lynne Rosen, 46, were found by the manager of a Brooklyn apartment building with plastic bags over their heads and tubes attached to a canister of helium, police told CNN.
The bodies were in a sitting position on a couch, their hands together, and two suicide notes were found, investigators said.
"I can't take it anymore, my wife is in too much pain," one of the notes read, without further explanation.
Littig, a motivational speaker, and Rosen, a psychotherapist, hosted an hourlong show Thursday mornings that focused on personal development and growth.
The couple also led a "life coach" consulting company, Why Not Now, CNN reported.