Issa, who appeared on CNN's "State of the Union," accused the White House spokesperson, Jay Carney, of lying by stating that the targeting originated in a Cincinnati office.
"Their paid liar, their spokesperson ... he's still making up things about what happens in calling this local rogue," Issa said.
He also said that officials who could have stopped the wrongdoing knew about the incidents.
"My gut tells me that too many people knew that this wrongdoing was going on before the election," he said. "But certainly people knew it was happening that could have done something and would have done something, I'm sure, if these had been progressive groups or groups that supported the president."
Issa also commented on the alleged wire tapping of reporters during his appearance on CNN.
He said Attorney General Eric Holder could have been more truthful when, under oath, he said he had nothing to do with the potential prosecution of a journalist -- even though Holder himself approved a search warrant later in an unrelated case.
"This attorney general maliciously covered up and will not give us the facts," Issa said.