Parents should consider a child's age when offering advice on what to do if a strangers approaches in public, WXMI-TV, Grand Rapids, Mich. Young children generally require shorter, more specific instructions than older children.
Children should be encouraged to tell a parent or other adult immediately if anything out of the ordinary happens, law enforcement officials stress.
The initiative is dubbed "Take 25" -- encouraging parents to spend 25 minutes on the 25th of May to address safety with children.
The National Center for Missing or Exploited Children encouraged the public to view images of missing children on the FBI website and offer any information on the cases possible.
The Colorado Bureau of Investigation said Amber Alerts are sent to all cellphone users in areas where children are abducted, if the phones are enabled with a Wireless Emergency Alert system.
President Ronald Reagan proclaimed National Missing Children Day to commemorate the disappearance of Etan Patz, a New York child who disappeared while walking to his school bus May 25, 1979.
Patz was the first missing child whose face was put on milk cartons. His case has never been solved.