Burwell replaces Jacob Lew, now President Obama's secretary of the treasury. The Senate vote was 96-0, The Hill reported.
"I am pleased that the Senate took bipartisan action today to confirm Sylvia Mathews Burwell as the director of the Office of Management and Budget," Obama said. "Sylvia shares my commitment to growing our economy, shrinking our deficits in a balanced way, and reigniting a rising, thriving middle class. Sylvia has spent a career fighting for working families, and she was part of an OMB team that presided over three budget surpluses in a row."
Burwell was deputy chief of staff for policy in the administration of President Bill Clinton. More recently she has been president of global development for the Bill and Melinda Gates Foundation and, since January 2012, president of the Walmart Foundation.