The tentative publication date is June 2014 and likely will include a book tour, fueling speculation about whether Clinton will make a presidential run in 2016, USA Today reported.
Financial terms were not disclosed. Clinton received $8 million for her 2003 memoir, "Living History," also published by Simon & Schuster.
The as-yet untitled book will use a "number of dramatic moments" when Clinton was secretary of state "to frame her thoughts about the recent history of U.S. foreign policy and the urgent, ongoing need for American leadership in a changing world," the publisher said.
Clinton will write about her role in, and reflections on, events such as the killing of al-Qaida founder Osama bin Laden, the overthrow of Moammar Gadhafi's regime in Libya, the transitions in Iraq and Afghanistan, the Arab Spring, the shift to the Asia-Pacific region and building diplomatic coalitions to deal with Iran and North Korea, Simon & Schuster said.
"The book will also address many of the major trends reshaping the global landscape of the 21st century," the publisher said, "trends in economics, energy and climate change, democracy and human rights, the critical role of women and girls, technology and innovation, health and human development, and more."
Notable deaths of 2014 [PHOTOS]