The fire was reported about 5 a.m. EDT Saturday at a farm owned by Shawn Rhodes.
Rockingham County Fire Chief Jeremy Holloway said the chicken house was almost gone when firefighters arrived at the scene, WHSV-TV, Harrisonburg, Va.
The cause of the fire was under investigation. Holloway said he believes the fire originated in a room where a computer system that runs the facility's heater is kept.
No injuries were reported.
Rhodes said he will get busy Monday, cleaning up and then will "try to build it back."