The fire began in Flagler County, with winds spreading the blaze to Volusia County and within Ormond Beach's city limits, Pat Kuehm of Volusia County Fire Services told NBC News.
I-95 and SR 429 had reopened in the evening after being closed for several hours, the Orlando Sentinel reported.
However, the fire was zero percent contained as 100 firefighters fought the flames with help from helicopters and bulldozers, NBC said.
The fire started about 4 miles west of Ormond Beach Airport, south of Daytona Beach. The cause was unknown.