The student, identified as Edmond A. St. Clair, 21, was stabbed during an altercation around 9 p.m. Saturday on the Somerset County campus, the Baltimore Sun reported.
Campus police were alerted to the stabbing when a man, identified as the victim's brother, ran up to a female officer and reported the incident.
The officer found St. Clair lying on the roadside next to a Honda with injuries to his upper torso.
St. Clair was transported to a local hospital where he was pronounced dead shortly after 9:30 p.m.
Police said St. Clair was a passenger in the Honda, which his brother was driving. Another man was in the back seat.
Witnesses told police that the three were driving through campus when they encountered three or four people in the street. The suspects and the three in the car got into some sort of altercation that ended with St. Clair being stabbed with an as yet unidentified weapon, police said.
Police identified the suspects as African American males in their late teens or early 20s.
The stabbing was over what appeared to be an argument or ongoing dispute, police said.