Brandon Brown, 22, of Marrero, turned himself in to police Tuesday afternoon and was booked on four counts of attempted first-degree murder, The (New Orleans) Times-Picayune reported Wednesday.
Deron Bridgewater, 23, also of Marrero, turned himself in Monday, police said.
A third person of interest is being sought.
Bridgewater and two other men are believed by police to have been involved in an argument with an 18-year-old man outside a Bourbon Street strip club Saturday that ended with four people being shot.
Three of the four wounded have been released from the hospital. The 18-year-old, who police believe was the intended target of the shooting, remains hospitalized in stable condition.