Sheriff's deputies were sent to a residence in the western part of the county about 4 a.m. Sunday and found all five victims unconscious, the Orlando Sentinel reported.
It wasn't known what kind of drugs were involved, the newspaper said.
One youth, identified as Krystopher Sansone, 17, died at a hospital, the sheriff's office said.
Three of the youths were reported in stable condition and one was released from a hospital.
Investigators said they had not determined if criminal charges would be filed.