Conyers Police Department official Mike Waters said two adults and a 5-year-old-boy escaped the blaze Tuesday, but the other children -- three boys and a girl -- were found inside the home and pronounced dead, WGCL-TV, Atlanta, reported Wednesday.
The children's grandmother was at the house when the fire broke out and was uninjured, fire officials said.
Four police officers arrived less than a minute after the call was made and entered the house with fire extinguishers, but were forced back out by the flames, Waters said.
The 5-year-old boy who survived was thrown from a second-story window by his mother, who also jumped to safety, WGCL said. The mother sustained severe burns, fire officials said.
The cause of the fire was under investigation.