Jason Kilar, chief executive officer of Hulu for more than five years, announced his decision to employees in an email Friday, The Hollywood Reporter said.
Chief technology officer Rich Tom will also be leaving the company, Kilar said.
"I've been so fortunate to play a role in this amazing, ongoing journey," Kilar said. "My decision to depart has been one of the toughest I've ever made."
Hulu, which streams television shows and movies online, brought in $695 million in 2012 and is worth about $2 billion.
"And while the above outputs are impressive and laudatory, the things that have clearly brought the most joy to my heart (and what I believe to be the most important inputs in our business) have been this team and the values and principles we hold dear," Kilar said.
Hulu has yet to comment on Kilar's announcement.