Dora Betancourt, a caseworker with the Florida Department of Children & Families, said Geralyn Graham "did not say she was upset, she did not seem upset," WTVJ-TV in Miami reported.
Rilya Wilson, who was in the foster care system, vanished more than 10 years ago, while she was in the care of Graham and her partner, Pamela Graham, The Miami Herald reported. The two women are not related.
The little girl's body has never been found.
Betancourt, who took the witness stand Tuesday, said when she visited the Grahams' home in the Miami area looking for the girl Geralyn told her a caseworker she could not name had taken her for a psychiatric treatment. Betancourt said there was no mention of that in Rilya's records.
Graham's lawyers argue Rilya could still be alive. Graham allegedly confessed the killing to a cellmate, but there is no physical evidence.