Obama signed a proclamation that marked the 20th anniversary of the observance.
"We reaffirm that the struggle to ensure the rights of every person does not end at our borders but extends to every country and every community," the president said.
The United States is one of 154 countries that signed the Convention of the Rights of Persons with Disabilities, Obama said in the proclamation, stating that injustices against people with disabilities "are an affront to our shared humanity."
"While Americans with disabilities already enjoy these rights at home, they frequently face barriers when they travel, conduct business, study or reside overseas," Obama said.
The United States is reaffirming its position "as the global leader on disability rights" and encourages "inclusion, equal opportunity, full participation, independent living and economic self-sufficiency for persons with disabilities worldwide," the president said.
"We know our work will not be finished until the inherent dignity and worth of all persons with disabilities is guaranteed."