Police Chief Chris Walsh told reporters the motive for the attacks was not clear but it appeared all three of the dead shared some sort of relationship, the Casper Star-Tribune reported. Walsh did not identify any of the dead, pending notification of their families, and declined to describe the weapon, other than to say it was an "edged weapon."
Walsh said the suspect was not a student at the college. He said no firearms were involved and no suspects were at large.
Police cordoned off a street in a part of Casper where there were reports of a body on the street, the newspaper said. One neighbor said the body was clothed in pajamas.
Police found the suspect and the other victim in a third-floor classroom at the school's physical sciences building.
Delina Barbosa, a student at the college, told the Star-Tribune she was in class at about 9:10 a.m. MST when a college employee told students they needed to evacuate immediately.
The campus was locked down for a time. The lockdown was lifted but students were advised to restrict their on-campus movements, the report said.
Natrona County School District officials put schools on lockdown as well, and the Wyoming Medical Center was on lockdown for about 30 minutes, the newspaper said.
Casper College said counselors would be available and employees not involved in the school's response to the attack were free to go home for the day.