The accident occurred Wednesday morning as 13 students aboard the bus traveled to Holy Trinity elementary school, the Hartford Courant reported.
A school spokesman said two students were treated by the school nurse for minor injuries that included split lips.
The pickup truck driver, who struck a utility pole before hitting the bus head-on, had serious injuries and was transported to MidState Medical Center in Meriden, authorities at the scene of the accident said.
'SNL': 'Anchorman 2' cast, One Direction sing 'Afternoon Delight' [VIDEO]
Wisconsin business offering 'therapeutic cuddling' forced to close