The California Highway Patrol said a minivan and a Toyota Prius crashed when the Prius apparently veered into oncoming traffic on Highway 50 near Placerville.
Two adults and a child in the Prius were killed as was a 4-year-old passenger in the minivan, officers told the Sacramento Bee.
A set of 1-year-old twins in the van and a 10-year-old in the Prius were among the injured.
Exploding whale video goes viral on Internet
Wisconsin business offering 'therapeutic cuddling' forced to close