The arrests came after local, state and federal authorities built a racketeering case against 33 members of the Bloods and local sets of the gang, including the Mohawk Boys, the Bullet Boys, the Fly Goons Lumberjacks and the Marlin Boys, the Orlando Sentinel reported.
Authorities are still searching for 12 other members of the gang.
Metropolitan Bureau of Investigation Director Larry Zwieg said the gang member committed an array of crimes, including homicides, drug trafficking and identity theft.
"The crimes were all over the map," he said.
The investigation, called "Operation Strong Arm," was centered around Jabarus Nathan, identified by MBI as the leader of the organization.
Other high-ranking members of the gang who were charged include Justin Dickson, Santana Sutton Sr., Lincoln Granston, Colin Wilson, Santana Sutton Jr. and Travis Jackson.