The Republican-leaning group will spend $343,000 to air the commercials beginning Friday through Oct. 10, Politico reported.
The ads will point to what AFF considers Obama's shortcomings in reacting to attacks last month on U.S. consulates and embassies across the Muslim world.
In the ad, a speaker says: "Sept. 11, 2012: Our ambassador is murdered. U.S. embassies under attack. Our president? Skips his security briefing the next day to attend a fundraiser in [Las] Vegas. Al-Qaida surges. Turmoil engulfs the Middle East. Our president? Too busy to meet with our closest ally in the region [Israeli Prime Minister Binyamin Netanyahu]."
The speaker closes by saying, "Is America leading? Are we safer? It's time for a leader who takes charge."
Americans are divided on Obama's approach to Libya and Egypt, the latest NBC/Wall Street Journal poll indicates. Some 45 percent of those surveyed said they approved of the way Obama handled the situation while 46 percent said they disapproved.
AFF was founded in 2007 by people who later worked for Mitt Romney's 2008 Republican presidential campaign.