The former president will close the gathering the next night, Sept. 6, by placing the name of President Barack Obama into nomination for a second term, reports CNN.
Clinton will speak on Wednesday, the second night of the convention, which begins Sept. 4 in Charlotte.
His speech is expected to focus on how Obama's agenda will help the middle class, a campaign aide told CNN.
Clinton is considered a good choice because he left the country with a surplus after two terms in office. He is considered still popular among voters.
Still, the former president's message could be muted. A professional football game is scheduled to be broadcast that evening.
Vice President Joe Biden is expected to speak about the administration's successes and challenges the following evening, the final night of the convention.
The evening will conclude with Obama's nomination.