Anyone who bought a ticket with the numbers 2, 4, 23, 38, 46, and the mega number 23 will win at least a share of the record jackpot. Those were the numbers drawn at 10:59 p.m. EDT.
Many people bought multiple tickets. Basketball player Chris Singleton of the Washington Wizards sent out a tweet to let fans know he would be spending $10,000, The Washington Post reported.
The 42-state lottery jackpot has rolled over 18 times since Jan. 25, the last time someone won the big one. The buying frenzy pushed the jackpot up from a record $540 million early Friday to $640 million by early afternoon.
A lottery official told CBS News the millions of tickets sold means there is a 90 percent probability that at least one will be a winner. But the odds of any individual ticket winning remain a daunting 1 in 176 million.
CBS asked two New York University mathematicians about number-picking strategies. Sylvain Cappell said choosing numbers others think are unlucky can reduce the chances of having to share a jackpot but there is no way to pick winners, while Charles Newman said he picks numbers at random.
Cappell had one further piece of advice: "I have to say the best strategy is not to buy the lottery ticket!"
The D.C. Lottery issued a commemorative "I Played the World's Largest Jackpot" ticket this week.
A typical Mega Millions drawing sells 250,000 tickets in the nation's capital.
The previous largest payout was $390 million in 2007, claimed by two players in New Jersey and Georgia.