The teens allegedly broke into Clint High School in Clint, Texas, a small farming town east of El Paso, and spray-painted walls, glued shut doors and glued light switches, the El Paso Times reported.
The teens were arrested late Monday. They were charged with engaging in organized criminal activity -- burglary of a building for breaking into the school --- and could face up to two years in jail.
The vandalism was reported just before 4 a.m. Monday, officials said.
The teens were being held on $20,000 bail each Tuesday afternoon.
Students returned to school Monday after being out on spring break last week.
The school district would not say whether the teens were students but the Times identified one of them, Manuel Cano, as quarterback of the school's football team.