The shark attack happened around 4 p.m. Wednesday, at a beach just south of the New Smyrna Beach jetty, the Orlando (Fla.) Sentinel reported.
Beach Patrol Capt. Tamara Marris said a girl, 15, was bitten on her ankle and a boy, 17, on his calf.
Both were taken to a hospital and treated for non-life-threatening wounds, Marris said.
Marris said the two teens were not at the beach together and that they were in waist-deep water when attacked.
Beach Patrol officers cleared people in the area from the water after the attack, said Marris.