Succeeding O'Donnell will be Melanie Kaye, who most recently worked at a Washington, D.C.-area advertising and communications consulting firm, the vice president's office said Monday in a release.
Jill Biden said O'Donnell would be working on projects based in Europe.
"Since Inauguration Day, Courtney has served as a trusted adviser to me and our entire team," Jill Biden said. "Her expertise, graceful demeanor and tireless work ethic have been invaluable not just to me but to the entire office of the vice president."
Before her work in the advertising-consulting field, Kaye was press secretary for former Wisconsin Gov. Jim Doyle.
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