Investigators say they're trying to determine the cause of the fire, which started early Monday morning and burned through Pro Exotics and five other businesses in an industrial park, KDVR-TV, Denver, reported.
Former NFL player Chad Brown is the owner of the reptile store. He said about 3,000 snakes, including 2,000 African Bald Pythons, were killed. The only survivor, a boa constrictor, was taken to a veterinarian for treatment.
Investigators said it appears the fire was accidental.