Police served warrants on two properties in the city's Kensington area Monday following another raid late Sunday night in South Philadelphia, The Philadelphia Inquirer reported.
In the Monday raids one woman was arrested and a dozen dogs rescued, authorities said.
Weapons and narcotics were also found at one of the addresses, they said.
In the Sunday night raid, police and Pennsylvania Society for the Prevention of Cruelty to Animals investigators entered a home as a dogfight was in progress and arrested 15 people.
"Some of the biggest fighters in the city are here," George Bengal of the PSPCA said at the scene of the raid. "This was a fairly large operation."
The raids were the result of months of investigations, he said.
"These gentlemen have been on our radar for quite some time."