Lulu was 46, considered relatively old for gorillas, the New York Daily News reported Wednesday.
Lulu thrilled New Yorkers in 1972 when she delivered the first baby gorilla ever born at the zoo.
Lulu and Kongo's baby, dubbed Patty Cake in a city-wide naming contest, was born Sept. 3, 1972.
Columbus Zoo and Aquarium officials said Lulu died Monday after suffering seizures Saturday.
Other than arthritis, Lulu, a western lowland gorilla, had been in generally good health, they said.
Lulu was born in Africa and came to the Central Park Zoo in 1966 as a 2-year-old.