Press Secretary Robert Gibbs said on CNN's "State of the Union" that the pending reforms in healthcare and the financial industry would help keep the current Cabinet largely intact.
"I don't expect quite honestly big changes," said Gibbs. "I think we've had a very capable and good Cabinet that has helped move the president's agenda forward."
Gibbs said one significant change in the roster would come in a few weeks when a replacement for Larry Summers as Obama's top economic adviser is named.
Gibbs declined to say if the departure of key political strategist David Axelrod could be taken as confirmation that Obama had decided to run for re-election in 2012. He did, however, concede that appeared to be the plan.
"He has not told me that but I would assume most people are planning for that to happen," he said.