Appearing on ABC's "Good Morning America," the Transportation Security Administration boss said: "The bottom line is, we are always adapting and adjusting prior protocols. … If that means we need to adjust the procedures, then of course we're open to that."
He also told the Christian Science Monitor Monday body cavity searches are out.
Since a body cavity bomb needs an external trigger, he said, current screening methods might pick it up even if it could not detect the hidden explosives.
"So we are not going to get in the business of doing body cavities," Pistole said. "That is not where we are."
An ABC News employee said she was subjected to a "demeaning" search at Newark Liberty International Airport Sunday.
"The woman who checked me reached her hands inside my underwear and felt her way around," she said. "It was basically worse than going to the gynecologist."
"There should never be a situation where that happens," Pistole said.