Attorney Norman Yatooma, who represents the family of Tamara Greene, 27, killed in a drive-by shooting about six months after supposedly performing at a rumored, but never proved, wild party at the mayoral mansion, had asked for a third deposition session with Kilpatrick, the Detroit Free Press reported.
U.S. District Judge Gerald Rosen said Yatooma wasted time at two earlier depositions and refused to give him two more hours with Kilpatrick.
"It appears that I will have to venture a guess on my own of whatever else Kwame Kilpatrick doesn't know, doesn't remember, or won't talk about for fear of prosecution," Yatooma said after the ruling.
Kilpatrick is in federal prison awaiting trial on federal tax evasion charges.
Greene's family is suing Kilpatrick and the city, saying officials ordered Detroit cops to sabotage Tamara Greene's murder investigation.
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