Kathleen Folden, 56, of Kalispell, Mont., spent the night in the Larimer County jail after being arrested at the Loveland Museum Gallery, The Coloradoan of Fort Collins reported. Police said she used a crowbar to break through the plexiglass protecting the lithograph and then shredded it.
She is likely to be charged with criminal mischief, police said.
"The Misadventures of Romantic Cannibals" by Enrique Chagoya, a California artist and professor at Stanford University, has attracted protesters to the museum. Some local officials have tried to get the lithograph removed.
Part of the lithograph shows a man who could be Jesus Christ in a homosexual sex act.
Mark Michaels, an art dealer who was at the museum at the time of the attack, said he heard Folden asking "How could anyone desecrate my Lord?"
Jan Burreson, a spokesman for Loveland Police, said Folden was "very cooperative" after police arrived.