The raid targeted a militant hideout in the North Waziristan region along the border with Afghanistan, Pakistan's Geo News reported Tuesday.
Local sources told Geo News four missiles hit the hideout, killing at least nine people who were inside at the time.
The death toll rose to 11 after relief workers found two more bodies in the rubble.
An official in North Waziristan's main town of Miranshah told the BBC all the dead and injured belonged to the Hafiz Gul Bahadur group of Taliban that dominates the area.
Drone attacks in the border area have killed hundreds of people since January 2009.
Pakistan publicly objects to U.S. drone strikes but analysts say they believe the raids have the private backing of officials, the BBC said.