Police spokesman John White said officers received a call at 12:48 a.m. Monday about a man with a handgun, and found two men near West Alabama Place and South Hooker Street, The Denver Post reported.
Police said they gave commands to the men. White said one of the men obeyed but the other did not and then pulled what appeared to be a handgun.
Two officers fired, hitting the man multiple times, White said.
Police were trying to identify the dead man and the name of the other man had not been released, the Post reported.
The officers were placed on paid administrative leave.