Farrakhan said a Southern Baptist preacher was quoting recently as praying the president would die and added, "There are Christians praying for God to kill Obama," the Chicago Sun-Times reported.
"The white right is trying to set Barack up to be assassinated," the controversial leader of the black nationalist movement told about 20,000 followers in Chicago Sunday.
Obama has sought to distance himself from Farrakhan over anti-Semitic statements.
Farrakhan's 3 1/2-hour speech, laced with anti-Semitism, marked Saviours Day, commemorating the birth of W. Fard Muhammad, who founded the Nation of Islam 80 years ago.
"The Zionists are in control of the Congress," Farrakhan said.
Naming Obama advisers Timothy Geithner, Henry Paulson and Larry Summers, Farrakhan said: "Who does he have around him? The people from Goldman Sachs."
The Nation of Islam minister said the bailout rewarded the "bloodsuckers of the poor."
Anti-Defamation League Director Abraham Foxman said the 76-year-old Farrakhan's comments came as no surprise.
"It's the same Farrakhan: ugly and anti-Semitic," Foxman said. "With age, he doesn't get milder, he gets uglier."
Farrakhan called the earthquake that killed at least 700 people in Chile a divine warning to leaders in America and elsewhere, the Chicago Tribune reported.
"It's not an accident that a great earthquake took place in Chile," he said. "It (precipitated) what I have to tell you today of what's coming to America. You will not escape.
"I will speak to the kings and rulers of the world. I will speak to the pope and the religious leaders because you have to know that your time has come."