"Are we strong? Are we winners?" Massachusetts Gov. Deval Patrick asked the crowd estimated at 400 to 500 guests who paid between $100 and $1,000 to attend the event inside Jordan's Third Base Deck at the baseball stadium.
"We've got a moment in history right within our grasp to remake our present and our future ... to rebuild the sense of community, the connection that I have talked about and you have talked about and felt for so long," Patrick said.
Biden noted he was a U.S. senator under eight presidents, but "no president has had as much laid on his plate the first day of taking office as (President Barack Obama) has."
"We're at one of those inflection points in American history," he said. "Ladies and gentlemen, non-action is action. No administration has moved as fast" to tackle as many issues as the Obama administration.
Pulling the country out of its economic hard times and putting it on the road to prosperity "will be difficult" but "we have faith in the American people."
"We believe we need to build a platform for the economy of the 21st century," Biden said.
About 60 donors who paid $5,000 each were invited to a private dinner held in a separate area of the ballpark after the fundraiser.