Two teenagers and an 11-year-old boy were hospitalized, the (Memphis) Commercial Appeal reported.
Firefighters found the two-story house in the Orange Mound neighborhood in flames when they arrived at 5:45 a.m. The blaze was under control within 20 minutes.
The dead were identified by relatives as Melissa Poole, 38; Deon Poole, 18; Diamond Poole, 9; Dajanique Poole, 7; DaShaun Poole, 5; Arianna Poole, 4; and Rodney Poole, 1. Darius Poole, 16, and DeAndra Poole, 11, were injured, along with a 17-year-old girl whose name had not been released Saturday evening.
The injured teens were at the Regional Medical Center at Memphis, a hospital spokeswoman said. The boy was taken to LeBonheur Children's Medical Center.
All three were reported to be in good or fair condition.
Investigators were trying to determine the cause of the fire.