The three seniors face possible assault charges after the prank sickened five unwitting staff members, two of whom were hospitalized.
The cake was served at a party last week at the Brooklyn School for Global Studies. The New York Daily News said no one was suspicious because the alleged pranksters included a straight-A cheerleader.
Some of the teachers told the Daily News they were saddened by the incident because they had felt close to the students this year.
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