Appearing on ABC's "This Week with George Stephanopoulos," Biden said Bush was directly attacking Democratic presidential hopeful when he spoke to Israeli lawmakers and compared unspecified U.S. politicians to pre-World War II appeasers of Adolf Hitler.
"Some seem to believe we should negotiate with terrorists and radicals, as if some ingenious argument will persuade them they have been wrong all along," Bush said Thursday.
"This was a political hit. This was a hit. Not trying to make a point," Biden said Sunday.
Obama Friday said he was clearly the target of Bush's comments, although the White House says publicly he was not.
Biden, the chairman of the Senate Foreign Relations Committee, Sunday said Bush's "policy has been an abject failure."
"For (Bush) to call those who rightly see the need for talk as appeasers is delusional and for him to do it from abroad is disgraceful."