Clinton leads her closest rival in the Democratic field, Barack Obama, by 40 percent to 20 percent, while John Edwards is at 11 percent, The Philadelphia Daily News reported Thursday.
"But remember, there are plenty of undecideds, and nearly three out of five Democrats who have a preference say they could still change their minds," said poll director G. Terry Madonna. "So this thing could change on a dime."
The poll also indicated that the economy has replaced the war in Iraq as the top issue among both Republicans and Democrats in the Keystone State.
Sixty-seven percent of respondents said the economy is doing "not too well" or "not well at all."
"I think economic populism is going to play very well in Pennsylvania this year," Madonna said. "It's beginning to remind me of an election like 1992. When the economy goes bad, Pennsylvanians have looked to the government for help."