Mohammed Shbair, who has a doctorate in microbiology from the University of West Virginia, is expected to succeed Ismail Hainyeh as prime minister as part of the Palestinian Authority's effort to form a unity government and get the international boycott lifted, which was imposed after Hamas gained power.
Shabair is ideologically close to Hamas but is not an active member, Israel's Arutz Sheva news service said.
Among the conditions for lifting the boycott are that Hamas must recognize Israel and renounce all violence.
Hamas spokesman Fawzi Barhoum said the agenda of the proposed unity government "will not recognize Israel and will not include accepting the two-state solution," the report said.
The European Union welcomed Shabair's choice to lead a new unity government, but noted there will be no change in its conditions for lifting the sanctions, the report said.