The departure of Rauf Denktash, 81, comes as his own constituents have begun to join Greeks in wearying of his hard-line approach to politics, the Telegraph reported Friday.
Mehmet Ali Talat, the current prime minister who advocates a more conciliatory approach, is expected to succeed Denktash.
Like most Turkish Cypriots, Talat supports reunification and full integration into the European Union.
His recent success reflects a shift in Turkish Cypriot public opinion away from Denktash's isolationist policies.
2014: The Year in Music [PHOTOS]