The Jeddah-based organization said in a statement that reports of Jewish extremists threatening to destroy Islam's third holiest shrine were "extremely and serious."
"Any damage done to al-Aqsa mosque is bound to unleash the sentiments of anger of Muslims around the world and will lead to wide-spread troubles which are difficult to predict," the statement said.
"The dangers and consequences of damaging the mosque will have detrimental effect on international peace and security since al-Aqsa is regarded as Islam's third holiest shrine" after Mecca and Medina, the statement said.
The group reminded Israel it is "duty bound to protect holy places in line with international treaties."
Ha'aretz had reported Sunday that Israeli authorities feared an aerial attack on al-Aqsa mosque by Jewish extremists.