Miller completed 18-of-24 passes for 252 yards, hooking up with Dontre Wilson, Chris Fields and Corey Brown on scoring strikes, while running 11 times for 68 yards.
Carlos Hyde reeled off 147 rushing yards with two scores on 16 carries for the Buckeyes (8-0, 4-0 Big Ten), who remained undefeated in 20 games under head Coach Urban Meyer.
The Nittany Lions (4-3, 1-2) suffered their worst loss since 1899, with freshman quarterback Christian Hackenberg limited to 112 yards on 7-of-11 passing with a touchdown before exiting in the third quarter.
Tyler Ferguson picked up 125 yards on 12-of-23 efficiency and tossed a TD pass in relief.
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