Manziel had been limited in practice due to an injured throwing shoulder, but "Johnny Football" completed 25-of-35 passes for 305 yards and four touchdowns to get the Aggies (6-2, 3-2 SEC) back on track after last week's loss to Auburn.
Manziel got Texas A&M off to a fast start with three first-quarter TD passes. He was intercepted once, but the Aggies racked up 28 first downs and converted 7-of-11 third-down plays.
Brandon Williams ran for a TD for the Aggies. Derel Walker and Mike Evans both caught two TD passes and Howard Matthews ran an interception back for a score.
Patton Robinette filled in for injured Austyn Carta-Samuels and went 15-for-28 for 216 yards for Vandy (4-4, 1-4). Robinette completed a touchdown pass and ran in a 7-yard score.
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