Bridgewater was a solid 25-of-29 passing for 344 yards for the Cardinals (7-1, 3-1 ACC), who bounced back from their first loss of the season last weekend.
Gerald Christian, Damian Copeland and Dominique Brown were the recipients of Bridgewater's scoring passes, and the Cardinals accumulated 138 rushing yards to 20 for South Florida (2-5, 2-1).
The Louisville defense, which had been unable to stop UCF in the second half last week, held South Florida to a first-quarter field goal and 133 total yards.
The Bulls' starting quarterback, Bobby Eveld, was knocked out of the game late in the first half with an ankle injury. Steven Bench came off the bench and completed 5-of-14 passes for 73 yards and an interception.
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