Winston burnished his Heisman Trophy credentials with the impressive performance, going 22-of-34 through the air while also running for a touchdown for the Seminoles (6-0, 4-0 ACC).
His favorite targets were Rashad Greene and Nick O'Leary, who combined for 13 receptions, 307 yards and two touchdowns.
Devonta Freeman led FSU's ground game with 84 yards and a score on 21 carries.
Previously undefeated Clemson (6-1, 4-1) fell as Tajh Boyd managed to complete just 17-of-37 passes for 156 yards with a touchdown and two interceptions.
Man spent 15 hours in jail for plugging electric car into an outlet at a school
Toddler uninjured after being knocked over by Obama family dog