The Aggies (5-1, 2-1 SEC) were trailing 38-31 with 6:05 remaining in the fourth quarter, but Manziel sparked them to 10 straight points ending the game for the comeback win.
Manziel capped the drive with a diving touchdown run with 3:07 left to knot the score 38-38.
After Ole Miss (3-3, 1-3) failed to move the ball on its next possession, Manziel once again took over and reeled off runs of 12 and 13 yards.
After Tra Carson gained 8 yards on a third-and-1 effort, Lambo connected on a 33-yard, game-winning field goal as time expired.
Celebrity Breakups and divorces of 2014 [PHOTOS]